Paraspinal myopathy-induced intervertebral disc degeneration and thoracolumbar kyphosis in TSC1mKO mice model—a preliminary study

Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Chloe Xiaoyun Chan, Wen-Hai Zhuo,Elisa Marie Crombie, Tuan Chun Tan,Way Cherng Chen,Simon Cool,Shih Yin Tsai

The Spine Journal（2022）

引用 6|浏览17

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摘要

•TSC1 gene knockout in a mouse resulted in paraspinal muscle myopathy.•TSC1mKO mice is by far, the best model to study the pathological consequence of sarcopenia.•Paraspinal muscle myopathy was established as early as 9 months.•TSC1mKO mice developed disc degeneration and disc wedging at 9 months.•Kyphosis of the spine with disc height loss and vertebral body wedging followed.

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关键词

Intervertebral disc degeneration,Kyphosis,Micro-CT,Paraspinal muscle,Sarcopenia,Spinal loading,TSC1mKO

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