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Glutamine gluttony of efferocytes

Alison Jaccard,Xiaoyun Li,Ping-Chih Ho

NATURE METABOLISM（2021）

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Abstract
Dysfunctional efferocytosis impairs clearance of apoptotic cells in disease. A new study shows that glutamine catabolism supports efficient apoptotic cell efferocytosis via non-canonical glutamine transamination but not canonical GLUD1-dependent α-ketoglutarate production, in a process that may operate in human atherosclerosis.
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Key words
Atherosclerosis,Chronic inflammation,Metabolic diseases,Phagocytes,Life Sciences,general
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