Clinical applications of magnetic resonance imaging based functional and structural connectivity

•Connectomics can help treatment planning in epilepsy and neuro-oncology.•Tractography can help motor thalamus targeting and has potential with other targets.•Combined with other modalities, connectomics can help elucidate pathophysiology.•Lack of standards in image acquisition and processing limit widespread utilization.•Improved acquisition and process automation can increase reliability of these tools.