Clinical and bacterial characteristics of Pseudomonas aeruginosa affecting the outcome of patients with bacteraemic pneumonia
International Journal of Antimicrobial Agents(2021)
摘要
•High prevalence of extensively drug-resistant (XDR) Pseudomonas aeruginosa from patients with bacteraemic pneumonia.•Resistance to ceftolozane/tazobactam and ceftazidime/avibactam was related to the activity of VIM and GES carbapenemases.•High diversity of virulence factors was evident, including genes encoding type III secretion system and O serotype.•ST175 and ST235 were major high-risk P. aeruginosa clones with specific clonal backgrounds and distinct molecular markers.•Severe neutropenia, septic shock, inappropriate empirical antibiotics and XDR phenotype identified as prognostic factors.
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关键词
Pseudomonas aeruginosa,Antimicrobial resistance,Virulence,Whole-genome sequencing,Bacteraemic pneumonia,Mortality
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