Iron-Catalyzed Radical Cascade Cyclization Of Oxime Esters With Isocyanides: Synthesis Of 1-Cyanoalkyl Isoquinolines And 6-Cyanoalkyl Phenanthridines

An iron-catalyzed radical cascade cyclization of oxime esters with isocyanides for the synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines has been developed. This demonstrates excellent functional group tolerance and broad substrate scope. A diverse range of potentially valuable 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines were obtained in moderate to good yields.