Orexin (hypocretin) and addiction
TRENDS IN NEUROSCIENCES(2021)
摘要
Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of the orexin system in reward-seeking and addiction, as well as potential therapeutic opportunities for substance use disorders based on normalizing orexin function.
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关键词
dopamine,hypothalamus,plasticity,reward,substance use disorder
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