Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC

Zhengbo Song,Shifeng Lian, Silvia Mak,Maggie Zi-Ying Chow,Chunwei Xu,Wenxian Wang, Hoi Yee Keung,Chenyu Lu,Firaol Tamiru Kebede,Yanqiu Gao,Wah Cheuk,William Chi Shing Cho,Mengsu Yang,Zongli Zheng

Journal of Thoracic Oncology（2022）

引用 14|浏览29

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摘要

Intratumoral EML4-ALK isoforms may predict the efficacy of targeted therapy in ALK-rearranged NSCLC. Temporal changes of intratumoral fusion isoforms may result from differential selection pressures that a drug might have on one isoform over another. Larger studies on fusion heterogeneity using RNA sequencing are warranted.

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关键词

RNA sequencing,ALK fusion heterogeneity,Fusion isoforms,Crizotinib,ALK TKI

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