Androgen receptor contributes to microglial/macrophage activation in rats with intracranial hemorrhage by mediating the JMJD3/Botch/Notch1 axis
Neuroscience Letters（2021）
Abstract
•Overexpression of AR is identified after ICH in rats.•AR regulates the transcription of JMJD3.•JMJD3 mediates the activity of the Botch/Notch1 pathway.•JMJD3 inhibits microglial activity and secondary brain injury.•Oe-AR and si-Botch reverse the repressive effects of JMJD3 on microglial activation.
MoreTranslated text
Key words
Androgen receptor,Microglial/macrophage activation,Secondary brain injury,JMJD3,Botch/Notch1 signaling
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined