Minimal detectable change of the disc-fovea angle for ocular torsion assessment
OPHTHALMIC AND PHYSIOLOGICAL OPTICS(2022)
Abstract
Purpose The disc-fovea angle (DFA) is used as a relevant indicator of ocular torsion change in cyclovertical strabismus. However, interpretation of the variation in time must differentiate whether a real change has occurred or if the disparity is due to random measurement error. The aim of the study was to obtain the minimal detectable change (MDC) of the DFA. It represents the minimal variation between two measurements that may be considered a real ocular torsion change. Methods A prospective cross-sectional study was conducted in San Carlos Clinical Hospital of Madrid, Spain. Sixty healthy right eyes from 60 patients (31 men and 29 women) were recruited. Three digital fundus photographs were obtained, and between measurements, the patient moved their head away from the head support and then returned. Two observers quantified the DFA with software designed with MATLAB. Test-retest and interrater reliability were calculated. Results Mean participant age was 56.1 years (SD 16.6, range 25-85). Mean DFA was 8.1 degrees (SD 3.5, range 1.3-18.5). Test-retest reliability for Observer 1 (Ob1), Observer 2 (Ob2) and interrater reliability were excellent (ICC 0.80, 0.83 and 0.95, respectively). Precision was 2.9 degrees (Ob1) and 3.0 degrees (Ob2), and the MDC95 was 4.1 degrees (Ob1) and 4.2 degrees (Ob2). Bland-Altman analysis revealed an absence of bias and a homoscedastic distribution of the differences. Conclusions The MDC of the DFA in fundus photography was 4 degrees, which represents the minimal change that may be considered a real change in ocular torsion. This result may improve the interpretation of ocular torsion changes in surgery and clinical scenarios.
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Key words
cycloposition,disc-fovea angle,disc-fovea axis,minimal detectable change,ocular torsion,strabismus
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