Genetic Diversity and Drug Susceptibility Profiles of Multidrug-Resistant Tuberculosis Strains in Southeast China.
Infection and drug resistance(2021)
Abstract
Our data demonstrate that the Beijing genotype is the dominant lineage among MDR-TB strains circulating in Fujian. Thus, MDR-TB infections occurring within this province are not likely associated with recent transmission events. PZA and fluoroquinolone resistance profiles were found to be associated with clustered isolates. Mutation of is the main driver of MDR-TB PZA resistance and is associated with mutation sites scattered throughout the entire protein-coding region.
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Key words
Mycobacterium tuberculosis,genotype,multidrug resistance,pncA,pyrazinamide
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