Highlighting the Relevance of CD8(+) T Cells in Filarial Infections

The T cell immune responses in filarial infections are primarily mediated by CD4(+) T cells and type 2-associated cytokines. Emerging evidence indicates that CD8(+) T cell responses are important for anti-filarial immunity, however, could be suppressed in co-infections. This review summarizes what we know so far about the activities of CD8(+) T cell responses in filarial infections, co-infections, and the associations with the development of filarial pathologies.