Limited Association Between Ascorbate Concentrations and Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical Samples.

Christina Wohlrab,Margreet C M Vissers,Eleanor R Burgess,Maria Nonis,Elisabeth Phillips,Bridget A Robinson,Gabi U Dachs

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

We observed a re-distribution of ascorbate transporters in tumour tissue compared to normal cortex and a shift from native to modified SVCT2 in cell culture and clinical samples. Data presented here show that SVCT protein levels do not appear to predict intracellular ascorbate accumulation in RCC.

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关键词

Vitamin C, ccRCC, pRCC, SVCT1, SVCT2

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