Microglia Esprit De Corps: Sharing The Burden Of Eliminating Toxic Aggregates
CELL(2021)
摘要
Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus onmicroglia that ingest toxic aggregates of a-synuclein, finding that a-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.
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