Treatment Response and GWAS Risk Allele rs2514218 (C) of the Dopamine D2 Receptor Gene in Inpatients with Schizophrenia.

Margarita A Morozova,Tatyana V Lezheiko,Taissia A Lepilkina,Denis S Burminskiy,Sergey S Potanin,Allan G Beniashvili,George E Rupchev,Vera E Golimbet

Neuropsychobiology（2022）

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摘要

Our findings suggest that the risk variant at the DRD2 locus can be used as an indicator for patients' responses to antipsychotics without direct DRD2-blocking, thereby shortening the time needed for drug selection.

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关键词

Antipsychotic medication,Dopamine D2 receptor,Genome-wide association study risk variant,Schizophrenia,Treatment response

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