Antioxidant compounds of Kielmeyera coriacea Mart. with α-amylase, lipase and advanced glycation end-product inhibitory activities

Allisson Benatti Justino, Eder C. Santana,Rodrigo Rodrigues Franco,Julia Silveira Queiroz,Heitor Cappato Guerra Silva,Joed Pires de Lima,André Lopes Saraiva,Mário Machado Martins,Sérgio Antônio Lemos de Morais,Alberto de Oliveira,Luiz Ricardo Goulart Filho, Francisco José Torres Aquino,Foued Salmen Espindola

Journal of Pharmaceutical and Biomedical Analysis（2021）

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Abstract

•LC-ESI-MS/MS analysis identified various proanthocyanidins in K. coriacea inner bark.•Liquid fractionation increased polyphenols in the polar fractions.•n-Butanol fraction showed high antioxidant capacity and low cytotoxicity.•Lipid peroxidation and glycation inhibited by ethyl acetate and n-butanol fractions.•The repertoire of bioactive compounds inhibited α-amylase and pancreatic lipase.

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Key words

Antioxidants,Diabetes,Enzyme inhibition,Glycation,Polyphenols

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