LGR5, HES1 and ATOH1 in Young Rectal Cancer Patients in Egyptian.

Heba Morsy,Ahmed Gaballah,Mohamed Samir, Vandrome Nakundi,Mohamed Shamseya, Hanan Mahrous,Abeer Ghazal, Mervat Hashish,Waleed Arafat

Asian Pacific journal of cancer prevention : APJCP（2021）

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摘要

High LGR5 expression is indicative of poor prognosis among young Egyptian RC patients and is proposed as a predictive marker of resistance to neoadjuvant CRT. However, HES1 and ATOH1 expressions were not prognostic nor predictive of response to CRT. Overall, LGR5, HES1 and ATOH1 gene expression patterns among young onset RC patients, are in line with patterns encountered in older age groups.

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Gene expression,Young colon cancer,cance stem cells chemotherapy prognosis

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