Rational design of cell active C2-modified DGJ analogues for the inhibition of human -galactosidase A (GALA)

We report the rational design and synthesis of C2-modified DGJ analogues to improve the selective inhibition of human GALA over other glycosidases. We prepare these analogues using a concise route from non-carbohydrate materials and demonstrate the most selective inhibitor 7c (similar to 100-fold) can act in Fabry patient cells to drive reductions in levels of the disease-relevant glycolipid Gb3.