Involvement of RNA granule proteins in meiotic silencing by unpaired DNA (vol 11, jkab179, 2021)

G3-GENES GENOMES GENETICS(2021)

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摘要
In Neurospora crassa, expression from an unpaired gene is suppressed by a mechanism known as meiotic silencing by unpaired DNA (MSUD). MSUD utilizes common RNA interference (RNAi) factors to silence target mRNAs. Here, we report that Neurospora CAR-1 and CGH-1, homologs of two Caenorhabditis elegans RNA granule components, are involved in MSUD. These fungal proteins are found in the perinuclear region and P-bodies, much like their worm counterparts. They interact with components of the meiotic silencing complex (MSC), including the SMS-2 Argonaute. This is the first time MSUD has been linked to RNA granule proteins.
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关键词
meiotic silencing by unpaired DNA (MSUD), Neurospora crassa, P-bodies, RNA granules, RNA interference (RNAi)
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