Efficacy of non-pharmacological interventions in patients with overactive bladder: A protocol for systematic review and network meta-analysis

Background: Some meta-analyses have proved the superiority of non-pharmacological interventions in overactive bladder (OAB), but the best choice is still controversial. Aim: To assess the most effective interventions in female with OAB. Methods: Studies for relevant randomized controlled trials which compare different kinds of non-pharmacological interventions in females with OAB will be retrieved from 8 databases including PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang Database, VIP Database and China Biology Medicine disc, from inception to 1 January 2021. After screening titles and abstracts, detailed data including participates, interventions and outcomes will be extracted according to the eligible criteria. Then, Cochrane risk-of-bias tool will be used to assess the quality of the literature. The pairwise meta-analysis will be conducted by STATA. Network meta-analysis will be performed to compare and rank the effects of different non-pharmacological interventions, in terms of alleviation of symptoms, by OpenBUGS, R and STATA. Results: This network meta-analysis will present the best available evidence about non-pharmacological interventions for OAB to both relieve symptoms and improve life quality.