Preventing leprosy with retrospective active case finding combined with single-dose rifampicin for contacts in a low endemic setting: results of the Leprosy Post-Exposure Prophylaxis program in Cambodia

•SDR-PEP reduces the risk of developing leprosy.•We combined the intervention with retrospective case finding and piloted it in low-endemic Cambodia•A total of 10,410 contacts of 555 index patients were listed.•Overall, 72.0% of the contacts were traced, of whom 82.6% received SDR.•Thirty-three new leprosy patients were diagnosed.