A case of resistant multiple plantar warts cured with combined autologous platelet-rich plasma injection and topical salicylic acid 30%

Background Plantar warts are common benign cutaneous lesions affecting the plantar aspects of the feet; they are caused by infection of the keratinocytes by the human papillomavirus (HPV). The effective treatment of plantar warts is still a therapeutic challenge. Aim This study aimed to assess the possible clinical efficacy and safety of the combined intralesional autologous platelet-rich plasma (PRP) injection with local application of salicylic acid 30% solution in the treatment of multiple resistant plantar warts. Method In the present case, a 54-year-old immunocompetent male patient presented with multiple, bilateral resistant plantar warts. Results A complete clearance of the plantar warts was observed after three sessions of intralesional autologous PRP injections with one-month interval, combined with twice-daily local application of salicylic acid 30% solution between sessions. No recurrence was recorded after a nine-month follow-up from the last session. There were no reported side effects during or after the sessions. Conclusion The combined intralesional autologous PRP injection with topical salicylic acid is an effective, economic, and safe modality of treatment for multiple resistant plantar warts.