Teaching Principles of Place Cells.

Animals navigate within their surrounding environment to find food, shelter, and mates; this behavior forms one of the most basic means of survival. The vertebrate hippocampus acts as an integration hub for varied dynamic processes such as attention, memory, perception, and decision-making. This ultimately allows an animal to move efficiently in its surroundings in search of food or to escape from predators. Place cells are neurons located within the hippocampus which are triggered in response to an animal entering specific places in its local environment. John O' Keefe first described the firing patterns of these cells in 1976 in a paper published in Experimental Neurology. This was a pioneering effort in combining the efficacy of electrophysiological recordings with the value of behavioral approaches in freely moving animals. The author also presented testable hypotheses of plausible mechanisms governing place cell activation which in turn provided a conceptual scaffold for a diverse range of subsequent work in the field. This is an excellent paper for undergraduate education because it provides the historical context to an important research avenue while simultaneously showing how clear and concise hypotheses can emerge from studying how neural activity correlates with animal behaviour.