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Dihydrotestosterone regulation of cyclooxygenase-2 expression in bovine endometrial epithelium cells by androgen receptor mediated EGFR/PI3K/Akt pathway

Longfei Xiao,Wanxu Sun,Yue Su,Ning Lu,Yanan He,Xihui Sheng,Xiaolong Qi,Kai Xing,Yong Guo,Di Chang,Xiangguo Wang,Junjin Zhao,Hemin Ni

The Journal of Steroid Biochemistry and Molecular Biology（2021）

Cited 1|Views3
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Abstract
•DHT levels increased in the late pregnancy phase in bovine endometria.•DHT showed a dose-dependent increased COX-2 expression and PGF2α release in EECs.•DHT via AR mediated EGFR/PI3K/ Akt/NFkB pathway regulated COX-2 expression.
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Key words
Endometria,Endometrial epithelial cells,Dihydrotestosterone,Cyclooxygenase-2,EGFR
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