Method for establishing dyskinetic animals and application thereof

The invention relates to a method for establishing dyskinetic animals and an application thereof. The method utilizes a Prrt2 gene to reduce expression or inactivation of an animal, and combines specific experimental manipulation tools and operation methods to obtain a dyskinetic animal model. The animal model obtained by the method is the stable dyskinetic animal model exhibiting typical traits,can be used for studying dyskinesia diseases, and can be used for screening and testing of specific drugs.