The genetics of cardiac failure: Role of a G protein-coupled receptor polymorphism in therapeutic response in an Indian population.

Sudha Ramalingam, Shanmugasundaram Radhakrishnan, Tamilarasu Kaliappan,Rajendiran Gopalan,Meenu Subrahmanian,Ramalingam Sankaran

Journal of clinical and translational research（2021）

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摘要

This study presents a comprehensive clinicofunctional pharmacogenetic characterization of Gln41>Leu polymorphism in a cohort of Indian HF patients. Gln41>Leu polymorphism can confer improved cardiac function and reduce hospitalization, thus improving the quality of life in HF patients.

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GRK5,India,genotype,heart failure,polymorphism,β-blocker

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