Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype
Neuroscience & Biobehavioral Reviews（2021）
Abstract
•Inflammatory and trophic properties of microglia are independently linked to neuropsychiatric disease.•Microglia are a novel source of BDNF.•Microglial responses are influenced by sex and developmental stage.•Microglia can be induced to express therapeutically relevant trophic phenotype(s).•BDNF-TrkB signalling may underlie specific trophic phenotypes.
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2-AG,A2AR,ACTH,AD,ADP,Akt,ALS,AMPA,AMPK,AR,arg1,ATP,Axl,BCP,BDNF,CaM,CAMK,CAMK2a,cAMP,CB2R,CBC,CBP,CD11b,CD14,CD200R,CD206,CD45,CD68,CNS,CORT,COX-2,CRE,CREB,CRH,CRP,CSF-1,CUS,CX3CR1,DAMP,DHA,ERK1/2,FGF-2,FTY720,GABA,GC,GDNF,GLP-1,HMGB1,HPA,Hsp72,IBA-1,IFN-β,IFN-γ,IGF-1,IL,IL-10,IL-18,IL-1β,IL-23,IL-34,IL-6,iNOS,IRF-3,JNK/pJNK,LPS,LTP,MAL,MAPK,M-CSF/CSF-1,MDD,MeCP2,MerTK,MHC,MIA,MMP,mRNA,mTOR,MYD88,NE,NF-κB,NGF,NLRP3,NO,NOS,NSAID,NT-3,NT-4,NTRK2,P2X4R,P2X7R,P2Y12R,p38MAPK,PAMP,PD,PGE2,PI3K,PKA,Poly (I:C),PPAR,RAGE,ROCK,ROS,S1P,SIRPα,TIRAP,TLR,TNF-α,TRIF,TrkB,TrkB.FL,TrkB.T1
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