Indoor air pollution exposure is associated with greater morbidity in cystic fibrosis

•Exposure to higher levels of outdoor air pollution is associated with worse lung function and greater rates of pulmonary exacerbations in CF, but limited data on exposure to indoor air pollution exist.•Pediatric individuals exposed to secondhand smoke had a 0.60% predicted/year decrease in FEV1% predicted compared to pediatric individuals who were not exposed.•Pediatric individuals exposed to forced hot air had a 0.46% predicted/year decrease in FEV1% predicted compared to pediatric individuals who were not exposed.•Adults exposed to secondhand smoke had 42% increased yearly risk of hospitalization compared to those adults who were not exposed.•Future studies with qualitative indoor air pollution measurements are needed to further quantify exposure risks for the CF population.