Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Min Lu,Hongjun Zhang,Derun Li,Matthew Childers,Qinglin Pu,Rachel L. Palte,Symon Gathiaka,Thomas W. Lyons,Anandan Palani,Peter W. Fan,Peter Spacciapoli,J. Richard Miller,Hyelim Cho,Mangeng Cheng,Kalyan Chakravarthy,Jennifer O'Neil,Padmanabhan Eangoor,Adam Beard,Hai-Young Kim,Josep Sauri,Hakan Gunaydin,David L. Sloman,Phieng Siliphaivanh,Jared Cumming,Christian Fischer ACS Medicinal Chemistry Letters（2021）
关键词
Arginase inhibitor,structure-based drug design,oral bioavailability,cancer immunotherapy,proline
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