Identification of CHMP4C as a new risk gene for inherited dilated cardiomyopathy

Dilated cardiomyopathy（DCM） is a primary myocardial disease of unknown cause that is characterized by ventricular enlargement and ventricular systolic dysfunction（Reichart et al., 2019）. DCM exhibits obvious heterogeneity, and its outcomes extend from arrhythmia to heart failure. Early arrhythmia is a common condition that may progressively become aggravated, and death can occur at any stage of the disease. The most serious complications are heart failure and sudden death（Mc Nally et al., 2013）.