Single-cell Analyses of Human Pancreas: Characteristics of Two Populations of Acinar Cells in Chronic Pancreatitis.
American journal of physiology Gastrointestinal and liver physiology/American journal of physiology Gastrointestinal and liver physiology(2021)
Abstract
We conducted single cell RNA sequencing on pancreas tissue from five individuals. We identified eleven unique cell clusters including a large population of dedifferentiated cells as well as two unique clusters of acinar cells, one of which appears to exist in a transitional state. We also examined the cellular response of pancreas tissue to stimulation and identified affected genes and pathways, including pancreatic digestive enzymes.
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Key words
pancreas,pancreatitis,RNA-Seq,single cell
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