L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis

Sarah E Martchenko,Alexandre Martchenko,Andrew D Biancolin,Alison Waller,Patricia L Brubaker

Molecular Metabolism（2021）

引用 11|浏览15

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摘要

•L-cell Arntl is required for time-dependent GLP-1 secretion.•L-cell Arntl regulates metabolic as well as GLP-1 synthesis and exocytotic pathways.•Loss of L-cell Arntl results in altered colonic immune and microbial environments.

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关键词

Circadian,Colon,GLP-1,GLP-2,Immunity,Inflammation,Microbiome

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