Evaluation of the Drug‐drug Interaction Potential of Treosulfan Using a Physiologically‐based Pharmacokinetic Modelling Approach

Stephan Schaller,Frederico S. Martins,Pavel Balazki,Sonja Bohm,Joachim Baumgart,Ralf A. Hilger,Dietrich W. Beelen,Claudia Hemmelmann,Arne Ring

British journal of clinical pharmacology（2021）

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摘要

The aim of this work is the development of a mechanistic physiologically‐based pharmacokinetic (PBPK) model using in vitro to in vivo extrapolation to conduct a drug‐drug interaction (DDI) assessment of treosulfan against two cytochrome p450 (CYP) isoenzymes and P‐glycoprotein (P‐gp) substrates.

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关键词

anticancer therapy,drug-drug interaction,inhibitor,modelling and simulation,pharmacokinetics

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