MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

Prajkta Chivte,Zane LaCasse,Venkata Devesh R Seethi,Pratool Bharti,Joshua Bland,Shrihari S Kadkol,Elizabeth R Gaillard

Journal of Mass Spectrometry and Advances in the Clinical Lab（2021）

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摘要

•Comparison of COVID-19 RT-qPCR status with MALDI-ToF analysis over a wide m/z range.•≥90% agreement with RT-qPCR COVID-19 status in the selected biomarker ranges.•Host and viral proteins potentially present in each spectrum may enhance diagnostics.

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ACE2,AUC,COVID-19,Ct, cycle threshold, DTT,E Protein,EUA,FDA,IgA,IgG,IgM,LoD,M Protein,MALDI-ToF MS,N Protein,NP,RBD,RNA,ROC,S Protein,SARS-CoV-2,VEP,WHO

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