Synthesis, anti-diabetic and in silico QSAR analysis of flavone hydrazide Schiff base derivatives.

This study reports synthesis of flavone hydrazide Schiff base derivatives with diverse functionalities for the cure of diabetic mellitus and their inhibitor and studies. In this regard, Flavone derivatives has synthesized and characterized by various spectroscopic techniques. These compounds showed significant potential towards enzyme inhibition activity and found to be many fold better active than the standard Acarbose (IC = 39.45 ± 0.11 µM). The ICvalues ranges 1.0238.1 µM. Among these, compounds (IC = 4.6 ± 0.23 µM), (IC = 1.02 ± 0.2 µM), (IC = 7.1 ± 0.11 µM), (IC = 8.3 ± 0.34 µM), (IC = 7.4 ± 0.15 µM), (IC = 8.5 ± 0.27 µM) and (IC = 1.09 ± 0.26 µM) showed highest activity. It was revealed that the analogues having -OH substitution have higher activity than their look likes. The molecular docking analysis revealed that these molecules have high potential to interact with the protein molecule and have high ability to bind with the enzyme. Furthermore, pharmacokinetics, physicochemical studies were also performed for these derivatives. The bioavailability radar analysis explored that of all these compounds have excellent bioavailability for five (5) descriptors, however, the sixth descriptor of instauration is slightly increased in all compounds.Communicated by Ramaswamy H. Sarma.