Predictivity of standardized and controlled permeation studies: Ex vivo – In vitro – In vivo correlation for sublingual absorption of propranolol

•Assessment of the predictivity of standardized ex vivo vs. in vitro permeation studies.•Successful proof of concept for evaluation of oromucosal delivery of propranolol.•Strong multiple level C correlation of permeability to sublingual pharmacokinetics.•Ex vivo – in vivo point-to-point correlation within clinically relevant time period.