Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes

•22-hour glycemic control was assessed during and after a laboratory condition where sitting was interrupted with exercises.•Activities were performed once or twice per hour (6 or 3 min breaks respectively), and compared to uninterrupted sitting.•Following the lunch-time meal, glycemic control was significantly improved when sitting was interrupted once per hour.•When sitting was interrupted twice per hour, nocturnal glycemic control was improved when compared to uninterrupted sitting.