Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and space

Tze Ker Matthew Leong, Wen Shern Lo, Wei En Zen Lee,Benedict Tan, Xing Zhao Lee,Li Wen Justina Nadia Lee,Jia-Ying Joey Lee,Nivedita Suresh,Lit-Hsin Loo, Evan Szu,Joe Yeong

Advanced Drug Delivery Reviews(2021)

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Abstract
•The TME plays a key role in cancer biology and treatment.•In vitro tumor models can mimic the TME to study cancer, but need to be improved.•AI is primed to analyze the data output from tumor models.•AI can characterize the cellular and spatial composition of the TME.•AI can identify novel features and higher order relationships.
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Key words
Machine learning,Deep learning,Tumor models,Immunohistochemistry,Digital pathology,Tumor microenvironment
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