The genomics of heart failure: design and rationale of the HERMES consortium.

R Thomas Lumbers,Sonia Shah,Honghuang Lin,Tomasz Czuba,Albert Henry,Daniel I Swerdlow,Anders Mälarstig,Charlotte Andersson,Niek Verweij,Michael V Holmes,Johan Ärnlöv,Per Svensson,Harry Hemingway,Neneh Sallah,Peter Almgren,Krishna G Aragam,Geraldine Asselin,Joshua D Backman,Mary L Biggs,Heather L Bloom,Eric Boersma,Jeffrey Brandimarto,Michael R Brown,Hans-Peter Brunner-La Rocca,David J Carey,Mark D Chaffin,Daniel I Chasman,Olympe Chazara,Xing Chen,Xu Chen,Jonathan H Chung,William Chutkow,John G F Cleland,James P Cook,Simon de Denus,Abbas Dehghan,Graciela E Delgado,Spiros Denaxas,Alexander S Doney,Marcus Dörr,Samuel C Dudley,Gunnar Engström,Tõnu Esko,Ghazaleh Fatemifar,Stephan B Felix,Chris Finan,Ian Ford, Francoise Fougerousse, René Fouodjio,Mohsen Ghanbari,Sahar Ghasemi,Vilmantas Giedraitis,Franco Giulianini,John S Gottdiener,Stefan Gross,Daníel F Guðbjartsson,Hongsheng Gui,Rebecca Gutmann,Christopher M Haggerty,Pim van der Harst,Åsa K Hedman,Anna Helgadottir,Hans Hillege,Craig L Hyde,Jaison Jacob,J Wouter Jukema,Frederick Kamanu,Isabella Kardys,Maryam Kavousi,Kay-Tee Khaw,Marcus E Kleber,Lars Køber,Andrea Koekemoer, Bill Kraus,Karoline Kuchenbaecker,Claudia Langenberg,Lars Lind,Cecilia M Lindgren,Barry London,Luca A Lotta,Ruth C Lovering,Jian'an Luan,Patrik Magnusson,Anubha Mahajan,Douglas Mann,Kenneth B Margulies,Nicholas A Marston,Winfried März,John J V McMurray,Olle Melander,Giorgio Melloni,Ify R Mordi,Michael P Morley,Andrew D Morris,Andrew P Morris,Alanna C Morrison,Michael W Nagle,Christopher P Nelson,Christopher Newton-Cheh,Alexander Niessner,Teemu Niiranen,Christoph Nowak,Michelle L O'Donoghue,Anjali T Owens,Colin N A Palmer,Guillaume Paré,Markus Perola,Louis-Philippe Lemieux Perreault,Eliana Portilla-Fernandez,Bruce M Psaty,Kenneth M Rice,Paul M Ridker,Simon P R Romaine,Carolina Roselli,Jerome I Rotter,Christian T Ruff,Marc S Sabatine,Perttu Salo,Veikko Salomaa,Jessica van Setten,Alaa A Shalaby,Diane T Smelser,Nicholas L Smith,Kari Stefansson,Steen Stender,David J Stott,Garðar Sveinbjörnsson,Mari-Liis Tammesoo,Jean-Claude Tardif,Kent D Taylor,Maris Teder-Laving,Alexander Teumer,Guðmundur Thorgeirsson,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet, Danny Tuckwell,Benoit Tyl,Andre G Uitterlinden,Felix Vaura,Abirami Veluchamy,Peter M Visscher,Uwe Völker,Adriaan A Voors,Xiaosong Wang,Nicholas J Wareham,Peter E Weeke,Raul Weiss,Harvey D White,Kerri L Wiggins,Heming Xing,Jian Yang,Yifan Yang,Laura M Yerges-Armstrong,Bing Yu,Faiez Zannad, Faye Zhao,Jemma B Wilk,Hilma Holm,Naveed Sattar,Steven A Lubitz,David E Lanfear,Svati Shah,Michael E Dunn,Quinn S Wells,Folkert W Asselbergs,Aroon D Hingorani,Marie-Pierre Dubé,Nilesh J Samani,Chim C Lang,Thomas P Cappola,Patrick T Ellinor,Ramachandran S Vasan,J Gustav Smith

ESC heart failure（2021）

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摘要

HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

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关键词

Association studies,Biomarkers,Cardiomyopathy,Genetics,Heart failure

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