Prognostic Significance Of Volume-Based F-18-Fdg Pet/Ct Parameters And Correlation With Pd-L1 Expression In Patients With Surgically Resected Lung Adenocarcinoma

The aim of this study was to retrospectively analyze F-18-FDG positron emission tomography/computed tomography (F-18-FDG PET/CT) metabolic variables, programmed death-ligand 1 (PD-L1) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) tumor expression, and other factors as predictors of disease-free survival (DFS) in patients with lung adenocarcinoma (LUAD) (stage IA-IIIA) who underwent surgical resection. We still lack predictor of immune checkpoint (programmed cell death-1 [PD-1]/PD-L1) inhibitors. Herein, we investigated the correlation between metabolic parameters from F-18-FDG PET/CT and PD-L1 expression in patients with surgically resected LUAD. Seventy-four patients who underwent F-18-FDG PET/CT prior to treatment were consecutively enrolled. The main F-18-FDG PET/CT-derived variables were primary tumor maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Surgical tumor specimens were analyzed for PD-L1 and p-STAT3 expression using immunohistochemistry. Correlations between immunohistochemistry results and F-18-FDG PET/CT-derived variables were compared. Associations of PD-L1 and p-STAT3 tumor expression, F-18-FDG PET/CT-derived variables, and other factors with DFS in resected LUAD were evaluated. All tumors were FDG-avid. The cutoff values of low and high SUVmax, MTV, and TLG were 12.60, 14.87, and 90.85, respectively. The results indicated that TNM stage, PD-L1 positivity, and high F-18-FDG PET/CT metabolic volume parameters (TLG >= 90.85 or MTV >= 14.87) were independent predictors of worse DFS in resected LUAD. No F-18-FDG metabolic parameters associated with PD-L1 expression were observed (chi-square test), but we found that patients with positive PD-L1 expression have significantly higher SUVmax (P = .01), MTV (P = .00), and TLG (P = .00) than patients with negative PD-L1 expression. F-18-FDG PET/CT metabolic volume parameters (TLG >= 90.85 or MTV >= 14.87) were more helpful in prognostication than the conventional parameter (SUVmax), PD-L1 expression was an independent predictor of DFS in patients with resected LUAD. Metabolic parameters on F-18-FDG PET/CT have a potential role for F-18-FDG PET/CT in selecting candidate LUAD for treatment with checkpoint inhibitors.