Pemphigus vulgaris and foliaceus localized to the nose: Report of 2 cases.
JAAD case reports(2021)
摘要
Pemphigus is a group of rare acquired autoimmune blistering diseases characterized by acantholysis and includes pemphigus vulgaris (PV), pemphigus foliaceus (PF), fogo salvagem, drug-induced pemphigus, and paraneoplastic pemphigus. PF is characterized by immunoglobulin G (IgG) autoantibodies against desmoglein (DSG) 1, primarily located in the granular layer of the epidermis, while PV is characterized by autoantibodies against DSG-3, primarily located in the mucous membranes. Autoantibodies against these molecules destroy the connection between keratinocytes, resulting in acantholysis and the formation of subcorneal blisters.
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