Safety and technical efficacy of pre-operative embolization of head and neck paragangliomas: A 10-year mono-centric experience and systematic review
Clinical Imaging(2021)
摘要
Objectives
To retrospectively evaluate the safety and technical success of pre-operative embolization (POE) of head and neck paragangliomas (HNP) in a single-center cohort over a 10-year period, and to benchmark our results with those derived from a systematic analysis of the available literature.
Methods
All consecutive HNP embolized between November 2010 and April 2020 were included and reviewed. In total, there were 27 HNP in 27 patients [8 (30%) males; 19 (70%) females; mean age 53 ± 16 years; range 30–86].Embolization technique, total procedure time, dose area product (DAP), complications, rate of HNP devascularization, and technical success (i.e. ≥80% devascularization of the HNP) were recorded and analyzed.A systematic analysis on the safety and technical success of POE was then conducted according to the Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Results
Twenty-one (21/27; 78%) HNP were treated with an endovascular approach and 6/27 (22%) with a percutaneous or combined (endovascular/percutaneous) technique. Mean total procedure time and DAP were 108 ± 48 min (range 45–235) and 92.5 ± 61.3 Gy·cm2 (range 19.9–276.0), respectively. Two (2/27; 7%) complications (one minor, one major) were observed.Mean HNP devascularization was 88 ± 15% (range 23–100) with technical success achieved in 24/27 (89%) HNP.Literature analysis revealed a pooled rate of complication and technical success of 3.8% (95% CI: 0.5–8.8%) and 79.0% (95% CI: 63.6–91.6%), respectively.
Conclusions
POE of HNP is safe and results in extensive devascularization in the majority of treated tumors.
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关键词
Paraganglioma,Carotid body tumor,Embolization,Outcome
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