Clec4e-Receptor Signaling in Myocardial Repair After Ischemia-Reperfusion Injury

Denise Veltman,Ming Wu,Peter Pokreisz,Piet Claus,Hilde Gillijns,Ellen Caluwé,Maarten Vanhaverbeke,Willy Gsell,Uwe Himmelreich,Peter R Sinnaeve,Stefan P Janssens

JACC: Basic to Translational Science（2021）

引用 14|浏览8

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摘要

•The role of the CLEC4E during myocardial healing after ischemia-reperfusion injury is unknown.•CLEC4E deletion is associated with reduced cardiac injury, inflammation, and left ventricular structural and functional remodeling.•CLEC4E is a promising target to modulate myocardial inflammation and enhance repair after ischemia-reperfusion injury.

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关键词

CLEC4E,inflammation,ischemia-reperfusion injury,magnetic resonance imaging,myocardial remodeling

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