LncRNA KCNQ1OT1 depletion inhibits the malignant development of atherosclerosis by miR-145-5p

Microvascular Research（2022）

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摘要

•KCNQ1OT1 is significantly upregulated in AS mice and ox-LDL-treated THP-1 cells.•KCNQ1OT1 silencing ameliorates lipid metabolic disorders and inflammation in AS model.•KCNQ1OT1 acts as a sponge for miR-145-5p.•KCNQ1OT1 silencing suppresses AS progression by upregulating miR-145-5p.

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关键词

KCNQ1OT1,miR-145-5p,Atherosclerosis,Ox-LDL

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