Building better biobetters: From fundamentals to industrial application

Karin M. Torres-Obreque, Giovanna P. Meneguetti, Jorge J. Muso-Cachumba,Valker A. Feitosa, João H.P.M. Santos,Sónia P.M. Ventura,Carlota O. Rangel-Yagui

Drug Discovery Today（2022）

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摘要

•Biobetters are improved biological drugs, usually with better pharmacokinetics.•Biobetters can be considered in between biosimilars and innovative biological drugs.•Biobetters take about 10 years of development with investments of $500 millions.•Glycosylation and PEGylation are the most common strategies to develop biobetters.•Innovative trends of genetic engineering are promising for biobetters development.

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关键词

Biobetter,Protein engineering,PEGylation,Glycoengineering,Biodegradable polymer,Fusion protein

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