Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells

Çiğdem Sevim,Mustafa Özkaraca,Mehtap Kara,Nergis Ulaş,Ali Sefa Mendil,Denisa Margina,Aristidis Tsatsakis

Environmental Toxicology and Pharmacology（2021）

引用 7|浏览16

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摘要

•3-MCPD and its metabolite glycidol are important food contaminats.•There was apoptosis in the cerebellum by the in 3-MCDP (10 mg/kg) and Glycidol (375 mg/kg) subacute treatment.•miR-21 gene expression levels significantly decreased in all groups.•The present work show genotoxic effects in rat brain tissue.

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关键词

3-MCPD,Glycidol,miR-21,PTEN-Akt pathway

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