Erythrocyte sedimentation: Effect of aggregation energy on gel structure during collapse
Physical review E(2021)
摘要
The erythrocyte (or red blood cell) sedimentation rate (ESR) is commonly
interpreted as a measure of cell aggregation and as a biomarker of
inflammation. It is well known that an increase of fibrinogen concentration, an
aggregation-inducing protein for erythrocytes, leads to an increase of the
sedimentation rate of erythrocytes, which is generally explained through the
formation and faster settling of large disjoint aggregates. However, many
aspects of erythrocyte sedimentation conform well with the collapse of a
colloidal gel rather than with the sedimentation of disjoint aggregates. Using
experiments and cell-level numerical simulations, we systematically investigate
the dependence of ESR on fibrinogen concentration and its relation to the
microstructure of the gel-like erythrocyte suspension. We show that for
physiological aggregation interactions, an increase in the attraction strength
between cells results in a cell network with larger void spaces. This
geometrical change in the network structure occurs due to anisotropic shape and
deformability of erythrocytes and leads to an increased gel permeability and
faster sedimentation. Our results provide a comprehensive relation between the
ESR and the cell-level structure of erythrocyte suspensions and support the gel
hypothesis in the interpretation of blood sedimentation.
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关键词
erythrocyte,Erythropoiesis
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