Revision In The First Steps Of The Biosynthesis Of The Red Antibiotic Prodigiosin: Use Of A Synthetic Thioester To Validate A New Intermediate
RSC CHEMICAL BIOLOGY(2021)
摘要
A biosynthetic pathway for the red-antibiotic, prodigiosin, was proposed over a decade ago but not all the suggested intermediates could be detected experimentally. Here we show that a thioester that was not originally included in the pathway is an intermediate. In addition, the enzyme PigE was originally described as a transaminase but we present evidence that it also catalyses the reduction of the thioester intermediate to its aldehyde substrate.
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关键词
red antibiotic prodigiosin,synthetic thioester,biosynthesis
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