Design and structural bioinformatic analysis of polypeptide antigens useful for the SRLV serodiagnosis

Angela Ostuni,Magnus Monné,Maria Antonietta Crudele,Pier Luigi Cristinziano,Stefano Cecchini,Mario Amati, Jolanda De Vendel,Paolo Raimondi,Taxiarchis Chassalevris,Chrysostomos I Dovas,Alfonso Bavoso

Journal of Virological Methods（2021）

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摘要

•Clustering analysis allows to design a set of representative viral protein antigens.•Modelling and Molecular Dynamics help to perform a conformational epitope prediction.•Viral antigen biosynthesized by recombinant DNA technology are useful in the SRLV serodiagnosis.

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关键词

Protein clustering,Antigen design,Modelling and structural analysis,Molecular dynamics,Circular dichroism,ELISA test,SRLV serodiagnosis

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