Synephrine and caffeine combination promotes cytotoxicity, DNA damage and transcriptional modulation of apoptosis-related genes in human HepG2 cells

Tainá Keiller Leão,Diego Luís Ribeiro,Ana Rita Thomazela Machado,Tássia Rafaela Costa,Suely Vilela Sampaio,Lusânia Maria Greggi Antunes

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2021）

引用 7|浏览20

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摘要

•This study examined toxicogenomic effects of Synephrine (SN) and Caffeine (CAF).•SN/CAF combination induced cytotoxicity, cell death, and DNA damage in HepG2 cells.•Apoptosis (BCL-2/CASP9) and DNA repair (XPC) genes were up-regulated.•Downregulation of cell cycle CDKN1A gene expression was associated with apoptosis.•These harmful effects can be worrisome to consumers of thermogenic supplements.

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关键词

Nutrigenomic,Cytotoxicity,HepG2 cells,Comet assay,Gene expression

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