Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis

Dear Editor, The hallmarks of cancer comprise sev-eral distinct biological characteristics ac-quired during the multistep development of human tumors with the unique feature of genomic instability (Shen,2011).These cancer characteristics include sus-taining proliferative signaling,evading growth suppressors,resisting cell death,enabling replicative immortality,inducing angiogenesis,and activating invasion and metastasis (Chen et al.,2011;Song et al.,2018).Triple-negative breast can-cer (TNBC),an aggressive disease with in-creased risks for visceral metastases,has a poor prognosis due to unavailable and viable therapeutic targets (Bianchini et al.,2016).A TNBC diagnosis indicates that cancer cells test negative for three key receptors:estrogen receptor,proges-terone receptor,and human epidermal growth factor receptor 2 (Bianchini et al.,2016).The absence of these three recep-tors renders existing hormone and tar-geted therapies ineffective.